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In this disease, one of the codons in an important hemoglobin gene has changed from CTC to CAC, resulting in the amino acid valine instead of glutamic acid. Chemically, these two amino acids are very dissimilar, so this simple change has a significant effect on the structure of hemoglobin protein, causing the disease symptoms.A missense mutation might be less significant if the change is between two similar amino acids. For example, a change from CTC (glutamic acid) to CTG (aspartic…